2-Methylimidazo[1,2-a]pyridin-6-amine

Name: 2-Methylimidazo[1,2-a]pyridin-6-amine
Brand: ChemScene
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CAS No. 860258-05-5
Cat. No. CS-0035648
Purity≥97%
MDL No.MFCD09991758

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Methylimidazo[1,2-a]pyridin-6-amine|CS-0035648

Structure of 860258-05-5

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General Information

CAS No. 860258-05-5
Cat. No. CS-0035648
Purity ≥97%
MDL No. MFCD09991758
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₉N₃
Molecular Weight 147.18
Synonym(s) IMidazo[1,2-a]pyridin-6-aMine, 2-Methyl-
SMILES CC1=CN2C=C(C=CC2=N1)N

Description

2-Methylimidazo[1,2-a]pyridin-6-amine delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry applications. This bench-stable core integrates seamlessly into kinase inhibitors and targeted therapeutics, offering enhanced binding affinity through complementary π-stacking and hydrogen bonding interactions.

Application

2-Methylimidazo[1,2-a]pyridin-6-amine serves as a versatile heterocyclic building block for medicinal chemistry and catalyst development. Its fused imidazo[1,2-a]pyridine core provides robust scaffold stability and favorable electronic properties, enabling efficient coupling reactions and metal-catalyzed transformations. The 6-amino group facilitates derivatization via amide formation, alkylation, or electrophilic substitution, while the methyl substituent enhances metabolic stability and modulates solubility. This compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for high-throughput synthesis and API intermediate construction.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 43.32
LogP 1.22492
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Methylimidazo[1,2-a]pyridin-6-amine

CAS No. 860258-05-5

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