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CS-W001157 4
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5-(4-Aminophenyl)pyrrolidin-2-one

  • CAS No. 858234-86-3

  • Cat. No. CS-0972029
  • Molecule weight176.22
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(4-Aminophenyl)pyrrolidin-2-one|CS-0972029

Structure of 858234-86-3

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General Information

  • CAS No. 858234-86-3
  • Cat. No. CS-0972029
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂N₂O
  • Molecular Weight 176.22
  • Synonym(s) None
  • SMILES O=C1NC(C2=CC=C(N)C=C2)CC1

Description

5-(4-Aminophenyl)pyrrolidin-2-one features a conjugated arylamine linked to a pyrrolidinone scaffold, enabling integration into bioactive scaffolds. The electron-rich aniline moiety facilitates coupling reactions, while the lactam ring provides structural rigidity and hydrogen-bonding capacity. This compound serves as a key intermediate in medicinal chemistry for targeting kinase pathways and modulating protein-protein interactions.

Application

5-(4-Aminophenyl)pyrrolidin-2-one serves as a versatile building block in medicinal chemistry, enabling the construction of biologically relevant heterocyclic scaffolds. Its amine-functionalized aryl group facilitates direct coupling reactions and derivatization, while the pyrrolidinone core offers favorable solubility and metabolic stability. The compound exhibits bench stability and is compatible with standard synthetic protocols, making it well-suited for iterative synthesis campaigns in drug discovery.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.2199
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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