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Structure of 85730-36-5
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2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine features a trifluoromethyl group that enhances electron-withdrawing character and metabolic stability. This pyrimidine scaffold integrates readily into kinase inhibitors and pharmaceutical intermediates, offering high reactivity in cross-coupling and nucleophilic substitution reactions under standard conditions.
2-Chloro-6-(trifluoromethyl)pyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its reactivity facilitates nucleophilic substitution at the C2 position, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The amine functionality supports diverse coupling reactions, making it well-suited for modular synthesis of kinase inhibitors and other bioactive compounds. Bench-stable and readily purified, it functions reliably in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: