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Structure of 672-41-3
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6-(Trifluoromethyl)pyrimidin-4-amine features a trifluoromethyl group at the 6-position and an amino moiety at the 4-position on a pyrimidine core. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced metabolic stability and membrane permeability in bioactive compounds.
6-(Trifluoromethyl)pyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the pyrimidine amine functions as a reliable handle for Suzuki-Miyaura, Buchwald-Hartwig, and reductive amination transformations. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: