Methyl 6-amino-5-chloronicotinate

Name: Methyl 6-amino-5-chloronicotinate
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CAS No. 856211-63-7
Cat. No. CS-0456404
Purity≥98%
MDL No.None

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Methyl 6-amino-5-chloronicotinate|CS-0456404

Structure of 856211-63-7

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General Information

CAS No. 856211-63-7
Cat. No. CS-0456404
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇ClN₂O₂
Molecular Weight 186.60
Synonym(s) methyl 6-amino-5-chloropyridine-3-carboxylate
SMILES COC(=O)C1=CC(=C(N)N=C1)Cl

Description

Methyl 6-amino-5-chloronicotinate features a chlorinated pyridine core with complementary amino and ester functionalities, enabling direct incorporation into heterocyclic scaffolds. The para-chloro group enhances electrophilicity for cross-coupling reactions, while the primary amine facilitates derivatization under mild conditions. This bench-stable reagent streamlines synthesis of bioactive nitrogen-containing compounds.

Application

Methyl 6-amino-5-chloronicotinate serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine derivatives via standard coupling and cyclization protocols. The amino and chloro groups offer orthogonal reactivity for selective functionalization, while the ester moiety facilitates downstream transformations. Its bench-stable nature and compatibility with common reaction conditions make it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

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Computational Chemistry Data

TPSA 65.21
LogP 1.1038
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 6-amino-5-chloronicotinate

CAS No. 856211-63-7

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