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CS-W001157 4
Total: USD 88.00

6-Chloro-5-(trifluoromethyl)picolinic acid

  • CAS No. 855915-21-8

  • Cat. No. CS-W022487
  • Molecule weight225.55
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Chloro-5-(trifluoromethyl)picolinic acid|CS-W022487

Structure of 855915-21-8

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General Information

  • CAS No. 855915-21-8
  • Cat. No. CS-W022487
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃ClF₃NO₂
  • Molecular Weight 225.55
  • Synonym(s) 6-Chloro-5-trifluoromethyl-pyridine-2-carboxylic acid
  • SMILES O=C(O)C1=NC(Cl)=C(C(F)(F)F)C=C1

Description

6-Chloro-5-(trifluoromethyl)picolinic acid features a trifluoromethyl group at the 5-position and a chlorine substituent at the 6-position of the picolinic acid scaffold. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates, offering enhanced metabolic stability and improved membrane permeability in bioactive molecule design.

Application

6-Chloro-5-(trifluoromethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro substituent facilitates palladium-catalyzed cross-coupling. The carboxylic acid functionality allows direct amidation or esterification, supporting rapid derivatization for drug discovery campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.452
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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