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Structure of 855915-21-8
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6-Chloro-5-(trifluoromethyl)picolinic acid features a trifluoromethyl group at the 5-position and a chlorine substituent at the 6-position of the picolinic acid scaffold. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates, offering enhanced metabolic stability and improved membrane permeability in bioactive molecule design.
6-Chloro-5-(trifluoromethyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro substituent facilitates palladium-catalyzed cross-coupling. The carboxylic acid functionality allows direct amidation or esterification, supporting rapid derivatization for drug discovery campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: