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CS-W001157 4
Total: USD 88.00

(1-Benzyl-1H-pyrazol-4-yl)boronic acid

  • CAS No. 852362-22-2

  • Cat. No. CS-0046117
  • Purity≥98%
  • MDL No.MFCD04038760

*For research and further manufacturing use only, not for direct human use.

(1-Benzyl-1H-pyrazol-4-yl)boronic acid|CS-0046117

Structure of 852362-22-2

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General Information

  • CAS No. 852362-22-2
  • Cat. No. CS-0046117
  • Purity ≥98%
  • MDL No. MFCD04038760
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁BN₂O₂
  • Molecular Weight 202.02
  • Synonym(s) 1-Benzyl-1H-pyrazole-4-boronic acid
  • SMILES OB(C1=CN(CC2=CC=CC=C2)N=C1)O

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering functionalized pyrazole scaffolds with high efficiency. The benzyl group enhances solubility and stability during reaction setup, while the pyrazole core provides a rigid, electron-rich platform for further derivatization in medicinal chemistry applications.

Application

(1-Benzyl-1H-pyrazol-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its boronic acid functionality exhibits good bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures. The benzyl-protected pyrazole core provides orthogonal reactivity for downstream transformations, making it a practical choice for medicinal chemistry and process synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.28
  • LogP   -0.3888
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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