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CS-W001157 4
Total: USD 88.00

4-Chloro-5,6-difluoronicotinic acid

  • CAS No. 851386-32-8

  • Cat. No. CS-W023219
  • Purity≥95%
  • MDL No.MFCD09031172

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5,6-difluoronicotinic acid|CS-W023219

Structure of 851386-32-8

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General Information

  • CAS No. 851386-32-8
  • Cat. No. CS-W023219
  • Purity ≥95%
  • MDL No. MFCD09031172
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂ClF₂NO₂
  • Molecular Weight 193.54
  • Synonym(s) 4-Chloro-5,6-difluoropyridine-3-carboxylic acid
  • SMILES O=C(O)C1=CN=C(F)C(F)=C1Cl

Description

4-Chloro-5,6-difluoronicotinic acid features a trifluorinated pyridine core with orthogonal halogen substitution, enabling precise C–H functionalization and cross-coupling. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and serves as a key building block for bioactive molecules requiring enhanced metabolic stability and membrane permeability.

Application

4-Chloro-5,6-difluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its orthogonal reactivity profile supports direct functionalization and coupling reactions, facilitating the synthesis of bioactive molecules with enhanced metabolic stability. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for both small-scale exploratory synthesis and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.7114
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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