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CS-W001157 4
Total: USD 88.00

4-Chloro-5,6-difluoronicotinic acid

  • CAS No. 851386-32-8

  • Cat. No. CS-W023219
  • Purity≥95%
  • MDL No.MFCD09031172
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5,6-difluoronicotinic acid|CS-W023219

Structure of 851386-32-8

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Description

4-Chloro-5,6-difluoronicotinic acid features a trifluorinated pyridine core with orthogonal halogen substitution, enabling precise C–H functionalization and cross-coupling. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and serves as a key building block for bioactive molecules requiring enhanced metabolic stability and membrane permeability.

Application

4-Chloro-5,6-difluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its orthogonal reactivity profile supports direct functionalization and coupling reactions, facilitating the synthesis of bioactive molecules with enhanced metabolic stability. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for both small-scale exploratory synthesis and process development workflows.

General Information

  • CAS No. 851386-32-8
  • Cat. No. CS-W023219
  • Purity ≥95%
  • MDL No. MFCD09031172
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂ClF₂NO₂
  • Molecular Weight 193.54
  • Synonym(s) 4-Chloro-5,6-difluoropyridine-3-carboxylic acid
  • SMILES O=C(O)C1=CN=C(F)C(F)=C1Cl

Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.7114
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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