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Structure of 851386-32-8
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4-Chloro-5,6-difluoronicotinic acid features a trifluorinated pyridine core with orthogonal halogen substitution, enabling precise C–H functionalization and cross-coupling. This electron-deficient heterocycle integrates readily into pharmaceutical scaffolds and serves as a key building block for bioactive molecules requiring enhanced metabolic stability and membrane permeability.
4-Chloro-5,6-difluoronicotinic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its orthogonal reactivity profile supports direct functionalization and coupling reactions, facilitating the synthesis of bioactive molecules with enhanced metabolic stability. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it well-suited for both small-scale exploratory synthesis and process development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: