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CS-W001157 4
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tert-Butyl 3-iodopiperidine-1-carboxylate

  • CAS No. 850761-36-3

  • Cat. No. CS-W023198
  • Purity≥97%
  • MDL No.MFCD08059309

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 3-iodopiperidine-1-carboxylate|CS-W023198

Structure of 850761-36-3

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General Information

  • CAS No. 850761-36-3
  • Cat. No. CS-W023198
  • Purity ≥97%
  • MDL No. MFCD08059309
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈INO₂
  • Molecular Weight 311.16
  • Synonym(s) 1-BOC-3-IODO-PIPERIDINE
  • SMILES IC1CN(C(OC(C)(C)C)=O)CCC1

Description

tert-Butyl 3-iodopiperidine-1-carboxylate features a sterically hindered piperidine core with a reactive iodide at the 3-position, enabling efficient cross-coupling transformations. The tert-butyl carbamate group provides stability and ease of removal under mild acidic conditions, facilitating downstream functionalization in medicinal chemistry and process development workflows.

Application

tert-Butyl 3-iodopiperidine-1-carboxylate serves as a versatile building block for constructing piperidine-based scaffolds in medicinal chemistry. The iodide functionality enables reliable Suzuki, Stille, and Negishi cross-coupling reactions, while the tert-butyl carbamate group offers orthogonal protection and stability under standard reaction conditions. Its bench-stable nature and compatibility with diverse functional groups make it ideal for modular synthesis of complex heterocycles and drug candidates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   2.8209
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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