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CS-W001157 4
Total: USD 88.00

4,6-Dichloro-5-nitropicolinic acid

  • CAS No. 850544-26-2

  • Cat. No. CS-0534150
  • Molecule weight237.00
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-5-nitropicolinic acid|CS-0534150

Structure of 850544-26-2

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General Information

  • CAS No. 850544-26-2
  • Cat. No. CS-0534150
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂Cl₂N₂O₄
  • Molecular Weight 237.00
  • Synonym(s) 4,6-Dichloro-5-nitro-2-pyridinecarboxylic acid
  • SMILES O=C(C1=NC(Cl)=C([N+]([O-])=O)C(Cl)=C1)O

Description

4,6-Dichloro-5-nitropicolinic acid features a highly electron-deficient pyridine core flanked by two chlorine substituents and a nitro group at the 5-position. This configuration enhances its utility in cross-coupling reactions and as a building block for bioactive heterocycles. The molecule exhibits robust stability under standard bench conditions and integrates readily into synthetic sequences requiring strong electron-withdrawing functionality.

Application

4,6-Dichloro-5-nitropicolinic acid serves as a versatile building block for the synthesis of heterocyclic scaffolds and bioactive molecules. Its orthogonal reactivity—enabled by the nitro group at C5 and chlorine substituents at C4 and C6—facilitates selective functionalization in late-stage diversification. The compound exhibits good bench stability and compatibility with standard coupling reactions, enabling efficient access to complex pyridine-based architectures relevant to medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   93.33
  • LogP   1.9948
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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