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N2-Methylpyrazine-2,3-diamine

  • CAS No. 84996-40-7

  • Cat. No. CS-0097639
  • Molecule weight124.14
  • Purity≥97%
  • MDL No.MFCD08460070

*For research and further manufacturing use only, not for direct human use.

N2-Methylpyrazine-2,3-diamine|CS-0097639

Structure of 84996-40-7

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General Information

  • CAS No. 84996-40-7
  • Cat. No. CS-0097639
  • Purity ≥97%
  • MDL No. MFCD08460070
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈N₄
  • Molecular Weight 124.14
  • Synonym(s) 2-Amino-3-(methylamino)pyrazine
  • SMILES NC1=NC=CN=C1NC

Description

N2-Methylpyrazine-2,3-diamine features a pyrazine core with methyl and diamine functionalities, delivering enhanced solubility and stability in polar solvents. This bench-stable scaffold enables direct incorporation into bioactive molecule design, particularly for kinase inhibitors and heterocyclic drug candidates requiring nitrogen-rich, electron-deficient frameworks.

Application

N2-Methylpyrazine-2,3-diamine serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrazine-based scaffolds through standard coupling and cyclization protocols. Its dual amine functionality and inherent aromatic stability facilitate straightforward functionalization and orthogonal protection strategies. The molecule exhibits good bench stability and is readily purified by recrystallization or column chromatography, making it well-suited for medicinal chemistry campaigns and process development in API synthesis.

Synthesis

  • Route1
    • In-stock
      3-Bromopyrazin-2-amine|CS-W008796
      21943-12-4
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      74-89-5
    • ~%
    • In-stock
      N2-Methylpyrazine-2,3-diamine|CS-0097639
      84996-40-7

    References

    • Australian Journal of Chemistry, , vol. 35, # 11 p. 2299 - 2306

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.83
  • LogP   0.1005
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   1

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