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CS-W001157 4
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Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride

  • CAS No. 845909-49-1

  • Cat. No. CS-W006482
  • Purity≥97%
  • MDL No.MFCD09880187

*For research and further manufacturing use only, not for direct human use.

Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride|CS-W006482

Structure of 845909-49-1

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General Information

  • CAS No. 845909-49-1
  • Cat. No. CS-W006482
  • Purity ≥97%
  • MDL No. MFCD09880187
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₅ClFNO₂
  • Molecular Weight 211.66
  • Synonym(s) Ethyl 4-fluoropiperidine-4-carboxylate, HCl
  • SMILES CCOC(C1(F)CCNCC1)=O.Cl

Description

Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride features a fluorinated piperidine core with enhanced solubility and stability under standard conditions. This bench-stable, moisture-tolerant derivative facilitates direct incorporation into complex molecular architectures, particularly in medicinal chemistry campaigns targeting CNS-penetrant bioactive compounds.

Application

Ethyl 4-fluoropiperidine-4-carboxylate hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated piperidine scaffolds prevalent in bioactive molecules. Its stable, crystalline form facilitates handling and purification, while the carboxylate ester group supports diverse transformations including reduction, amidation, and coupling reactions. The fluorine substituent enhances metabolic stability and modulates electronic properties, making it valuable for constructing pharmacologically relevant heterocycles with improved potency and selectivity.

Synthesis

  • Route1

    References

    • US2012/88750 A1, ; Page/Page column 34; 35 ;
  • Route2

    References

    • US2012/88750 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   1.063
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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