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Structure of 845823-04-3
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4-Fluoro-2-methylthiophenol features a fluorine substituent at the para position and a methylthio group at the ortho position relative to the phenolic hydroxyl, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration enables selective coupling in cross-coupling reactions and facilitates incorporation into bioactive scaffolds requiring precise electronic tuning.
4-Fluoro-2-methylthiophenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its ortho-methylthio group facilitates directed metalation and subsequent functionalization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard coupling reactions, simplifying purification and integration into multi-step syntheses.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331-H315-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: