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Structure of 7079-48-3
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4-Fluoro-2-methylbenzenesulfonyl chloride is a reactive sulfonyl chloride featuring an electron-withdrawing fluorine and a methyl group in ortho relationship to the sulfonyl moiety. This electronic and steric configuration enhances its electrophilicity, enabling efficient sulfonation of nucleophiles under mild conditions. The compound exhibits excellent bench stability and moisture tolerance, simplifying handling in synthetic workflows.
4-Fluoro-2-methylbenzenesulfonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of the 4-fluoro-2-methylbenzenesulfonyl group into pharmaceutical and agrochemical intermediates. Its reactivity enables selective sulfonation of amines, alcohols, and thiols under mild conditions, with the fluorine and methyl substituents offering orthogonal functionalization potential. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: