N-Fmoc-N-ethyl-L-alanine

Name: N-Fmoc-N-ethyl-L-alanine
Brand: ChemScene
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CAS No. 84000-09-9
Cat. No. CS-0378006
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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General Information

CAS No. 84000-09-9
Cat. No. CS-0378006
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₀H₂₁NO₄
Molecular Weight 339.39
Synonym(s) N-Ethyl-N-{[(9H-fluoren-9-yl)methoxy]carbonyl}-L-alanine
SMILES OC([C@H](C)N(CC)C(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=O

Description

N-Fmoc-N-ethyl-L-alanine integrates a sterically hindered ethyl group at the N-terminus, enhancing solubility and reducing racemization during peptide synthesis. The Fmoc moiety enables efficient, orthogonal deprotection under mild basic conditions, streamlining chain elongation in solid-phase workflows.

Application

N-Fmoc-N-ethyl-L-alanine serves as a versatile building block in peptide synthesis, enabling the incorporation of ethylated amine functionality at the N-terminus. The Fmoc group provides orthogonal protection compatible with standard coupling protocols, while the N-ethyl substitution enhances metabolic stability and modulates solubility. This derivative facilitates efficient chain elongation and purification due to its bench-stable nature and compatibility with common deprotection conditions.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 66.84
LogP 3.7305
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 5

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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N-Fmoc-N-ethyl-L-alanine

CAS No. 84000-09-9

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