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CS-W001157 4
Total: USD 88.00

Methyl 6-fluoropicolinate

  • CAS No. 455-71-0

  • Cat. No. CS-W005576
  • Purity≥98%
  • MDL No.MFCD11110421

*For research and further manufacturing use only, not for direct human use.

Methyl 6-fluoropicolinate|CS-W005576

Structure of 455-71-0

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General Information

  • CAS No. 455-71-0
  • Cat. No. CS-W005576
  • Purity ≥98%
  • MDL No. MFCD11110421
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆FNO₂
  • Molecular Weight 155.13
  • Synonym(s) 6-fluoro-pyridine-2-carboxylic acid methyl ester
  • SMILES O=C(OC)C1=NC(F)=CC=C1

Description

Methyl 6-fluoropicolinate is a fluorinated pyridine derivative featuring a methyl ester group at the 6-position. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, offering enhanced metabolic stability and improved membrane permeability in bioactive compound design.

Application

Methyl 6-fluoropicolinate serves as a versatile building block in medicinal chemistry, enabling efficient construction of fluorinated heterocyclic scaffolds. Its ortho-fluorine substituent enhances electrophilicity at the pyridine ring, facilitating nucleophilic substitution and transition-metal-catalyzed coupling reactions. The ester functionality provides compatibility with standard transformations, including reduction to the alcohol or hydrolysis to the carboxylic acid. Bench-stable and readily purified by column chromatography, it functions as a key intermediate in the synthesis of bioactive molecules.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   39.19
  • LogP   1.0073
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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