CRBN ligand-225

Name: CRBN ligand-225
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CAS No. 83809-75-0
Cat. No. CS-0754985
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 83809-75-0
Cat. No. CS-0754985
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀N₂O₃
Molecular Weight 206.20
Synonym(s) 1-(4-Hydroxyphenyl)Dihydropyrimidine-2,4(1H,3H)-Dione
SMILES O=C1NC(=O)CCN1C2=CC=C(O)C=C2

Description

1-(4-Hydroxyphenyl)dihydropyrimidine-2,4(1h,3h)-dione features a phenolic hydroxyl group enabling hydrogen bonding and enhanced solubility in polar solvents. This scaffold integrates a dihydropyrimidinone core with aromatic substitution, offering structural stability and utility in medicinal chemistry for targeted synthesis of bioactive heterocycles under standard conditions.

Application

1-(4-Hydroxyphenyl)dihydropyrimidine-2,4(1H,3H)-dione serves as a versatile scaffold in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its hydroxylated aryl group enhances solubility and hydrogen-bonding capacity, while the dihydropyrimidinone core exhibits stability under standard synthetic conditions. The compound facilitates modular derivatization via amine coupling, electrophilic substitution, or oxidation reactions, supporting rapid analog generation for structure–activity studies.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 69.64
LogP 0.8385
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Urea

Building Blocks Functional Group Amide

Building Blocks Skeleton Aliphatic heterocycle compounds Other aliphatic heterocycles compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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CRBN ligand-225

CAS No. 83809-75-0

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