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CS-W001157 4
Total: USD 88.00

(3-Amino-2-methylphenyl)methanol

  • CAS No. 83647-42-1

  • Cat. No. CS-0134948
  • Purity≥98%
  • MDL No.MFCD00075028

*For research and further manufacturing use only, not for direct human use.

(3-Amino-2-methylphenyl)methanol|CS-0134948

Structure of 83647-42-1

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General Information

  • CAS No. 83647-42-1
  • Cat. No. CS-0134948
  • Purity ≥98%
  • MDL No. MFCD00075028
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO
  • Molecular Weight 137.18
  • Synonym(s) 3-Amino-2-Methylbenzyl Alcohol
  • SMILES OCC1=CC=CC(N)=C1C

Description

This bench-stable arylmethanol features a strategically positioned amino group flanking a methyl substituent, enabling direct incorporation into diverse heterocyclic frameworks. The ortho-amino functionality facilitates efficient metal-catalyzed coupling reactions and serves as a key handle for downstream derivatization in medicinal chemistry applications.

Application

(3-Amino-2-methylphenyl)methanol serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted benzimidazoles and other heterocyclic scaffolds. Its ortho-amino and benzylic alcohol functionalities offer complementary reactivity for sequential functionalization, including coupling reactions and cyclizations. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for use in multi-step synthetic sequences targeting bioactive molecules.

Synthesis

  • Route1

    References

    • US5256666 A1, ;
  • Route2

    References

    • Journal of the Chemical Society, , p. 304
  • Route3

    References

    • Chemical Communications, , # 25 p. 3162 - 3164

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   1.06952
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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