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CS-W001157 4
Total: USD 88.00

(4-(Benzyloxy)phenyl)methanol

  • CAS No. 836-43-1

  • Cat. No. CS-0105228
  • Purity≥96%
  • MDL No.MFCD00004654

*For research and further manufacturing use only, not for direct human use.

(4-(Benzyloxy)phenyl)methanol|CS-0105228

Structure of 836-43-1

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General Information

  • CAS No. 836-43-1
  • Cat. No. CS-0105228
  • Purity ≥96%
  • MDL No. MFCD00004654
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₄O₂
  • Molecular Weight 214.26
  • Synonym(s) 4-Benzyloxybenzyl alcohol
  • SMILES OCC1=CC=C(OCC2=CC=CC=C2)C=C1

Description

This benzyl ether-functionalized phenylmethanol offers enhanced solubility and stability in organic synthesis. The benzyloxy group provides a robust protecting group for phenolic hydroxyls, while the primary alcohol enables straightforward derivatization. Ideal for intermediate development in pharmaceutical and agrochemical applications.

Application

(4-(Benzyloxy)phenyl)methanol serves as a versatile building block for aromatic ether synthesis and heterocyclic scaffold construction. Its benzyloxy and primary alcohol functionalities enable orthogonal protection strategies and facilitate coupling reactions under standard conditions. The compound exhibits excellent bench stability and ease of purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V. Organic Letters, 2013 , vol. 15, # 9 p. 2278 - 2281
  • Route2
    • 4-Hydroxybenzyl alcohol Bisoprolol Alcohol Impurity|CS-0229718
      623-05-2
    • null|null
      100-39-0
    • ~93%
    • In-stock
      (4-(Benzyloxy)phenyl)methanol|CS-0105228
      836-43-1

    References

    • Lee, Jeewoo; Lee, Ju-Hyun; Kim, Su Yeon; Perry, Nicholas A.; Lewin, Nancy E.; Ayres, Jolene A.; Blumberg, Peter M. Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2022 - 2031
  • Route3
    • Tyrosol Metoprolol Impurity|CS-0214021
      501-94-0
    • null|null
      100-39-0
    • ~%
    • In-stock
      (4-(Benzyloxy)phenyl)methanol|CS-0105228
      836-43-1

    References

    • WO2012/38942 A1, ; Page/Page column 46-47 ; WO 2012/038942 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   2.7579
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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