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CS-W001157 4
Total: USD 88.00

3-Chloro-4-(Trifluoromethoxy)Benzaldehyde

  • CAS No. 83279-39-4

  • Cat. No. CS-W023075
  • Purity≥97%
  • MDL No.MFCD01631561

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-(Trifluoromethoxy)Benzaldehyde|CS-W023075

Structure of 83279-39-4

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General Information

  • CAS No. 83279-39-4
  • Cat. No. CS-W023075
  • Purity ≥97%
  • MDL No. MFCD01631561
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄ClF₃O₂
  • Molecular Weight 224.56
  • Synonym(s) None
  • SMILES O=CC1=CC=C(OC(F)(F)F)C(Cl)=C1

Description

3-Chloro-4-(trifluoromethoxy)benzaldehyde features a trifluoromethoxy group that enhances electron-withdrawal and metabolic stability, while the chloro substituent directs electrophilic substitution. This combination enables efficient coupling in Suzuki-Miyaura and Ullmann reactions, delivering complex heterocycles with high functional group tolerance under standard conditions.

Application

3-Chloro-4-(trifluoromethoxy)benzaldehyde serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to diverse heterocyclic scaffolds. Its electron-withdrawing trifluoromethoxy group enhances electrophilicity at the carbonyl center, facilitating nucleophilic additions and condensation reactions. The chloro substituent provides a handle for further functionalization via cross-coupling or substitution. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows requiring high chemical fidelity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   3.0511
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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