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Structure of 83265-56-9
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2-Amino-5-(trifluoromethoxy)benzoic acid features a trifluoromethoxy group that imparts enhanced metabolic stability and lipophilicity, while the ortho-amino functionality enables direct coupling in peptide synthesis. This electron-deficient aromatic scaffold serves as a key building block for bioactive heterocycles and pharmaceutical intermediates under standard conditions.
2-Amino-5-(trifluoromethoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical scaffolds. Its ortho-amino and carboxylic acid functionalities offer orthogonal reactivity for coupling, amidation, and cyclization reactions. The trifluoromethoxy group enhances metabolic stability and lipophilicity, making it valuable for optimizing drug-like properties. Bench-stable and readily purified by recrystallization, it functions efficiently in standard peptide coupling and transition-metal-catalyzed transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: