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CS-W001157 4
Total: USD 88.00

4-(Dimethylamino)nicotinic acid

  • CAS No. 83039-02-5

  • Cat. No. CS-0095623
  • Purity≥95%
  • MDL No.MFCD20654938

*For research and further manufacturing use only, not for direct human use.

4-(Dimethylamino)nicotinic acid|CS-0095623

Structure of 83039-02-5

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General Information

  • CAS No. 83039-02-5
  • Cat. No. CS-0095623
  • Purity ≥95%
  • MDL No. MFCD20654938
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀N₂O₂
  • Molecular Weight 166.18
  • Synonym(s) 4-(dimethylamino)pyridine-3-carboxylic acid
  • SMILES O=C(C1=C(N(C)C)C=CN=C1)O

Description

4-(Dimethylamino)nicotinic acid features a pyridine ring bearing an electron-rich dimethylamino group at the para position and a carboxylic acid functionality at C-4, enabling dual reactivity. This structural motif supports integration into bioconjugation workflows, where the acidic proton facilitates derivatization while the basic amine enhances solubility in polar solvents. The compound exhibits bench-stable behavior under standard handling conditions.

Application

4-(Dimethylamino)nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its pyridine core offers enhanced solubility and modulates electronic properties, while the carboxylic acid group facilitates direct coupling reactions. The dimethylamino substituent enhances nucleophilicity and enables facile derivatization, making it valuable for constructing drug-like scaffolds with improved metabolic stability and target affinity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   53.43
  • LogP   0.8458
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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