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Structure of 828918-24-7
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This chiral pyridine ligand features two oxazoline moieties bearing bulky diphenyl and isopropyl groups, delivering high enantioselectivity in transition metal catalysis. The steric bulk and electron-rich character enhance complex stability and stereocontrol.
2,6-Bis((R)-4-isopropyl-5,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine serves as a sterically hindered, chiral ligand that enables asymmetric catalysis in transition metal-mediated reactions. Its rigid oxazoline framework imparts high enantioselectivity in palladium- and copper-catalyzed cross-couplings, while the diphenyl-substituted dihydrooxazoline moieties enhance stability and functional group tolerance. The molecule exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic applications in medicinal chemistry and process development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: