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CS-W001157 4
Total: USD 88.00

H-D-HoPhe-OH

  • CAS No. 82795-51-5

  • Cat. No. CS-W017272
  • Purity≥98%
  • MDL No.MFCD00063091

*For research and further manufacturing use only, not for direct human use.

H-D-HoPhe-OH|CS-W017272

Structure of 82795-51-5

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General Information

  • CAS No. 82795-51-5
  • Cat. No. CS-W017272
  • Purity ≥98%
  • MDL No. MFCD00063091
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₃NO₂
  • Molecular Weight 179.22
  • Synonym(s) D-Homophenylalanine
  • SMILES O=C(O)[C@H](N)CCC1=CC=CC=C1

Description

H-D-HoPhe-OH is a bench-stable, moisture-tolerant dipeptide building block featuring a D-configured homophenylalanine residue. This synthetic handle integrates seamlessly into peptide sequences, offering enhanced metabolic stability and improved solubility in organic solvents.

Application

H-D-HoPhe-OH serves as a stable, bench-ready D-amino acid building block for the synthesis of peptidomimetics and bioactive oligomers. Its hydroxyphenylalanine side chain enables site-specific conjugation and structural modulation in therapeutic peptide design. The D-configuration enhances metabolic stability, while the carboxylic acid functionality supports direct coupling in solid-phase and solution-phase syntheses.

Synthesis

  • Route1
    • null|null
      100516-57-2
    • ~0%
    • In-stock
      L-Homophenylalanine|CS-M2900
      943-73-7
    • In-stock
      H-D-HoPhe-OH|CS-W017272
      82795-51-5

    References

    • Williams, Robert M.; Sinclair, Peter J.; Zhai, Dongguan; Chen, Daimo Journal of the American Chemical Society, 1988 , vol. 110, # 5 p. 1547 - 1557
  • Route2

    References

    • University of Southern California Patent: US6232467 B1, 2001 ;
  • Route3

    References

    • Journal of the American Chemical Society, , vol. 129, # 43 p. 13321 - 13326

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   1.0311
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   4

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