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Structure of 825-70-7
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5-Fluoro-2-methylindoline is a fluorinated indoline derivative featuring a methyl group at the 2-position and a fluoro substituent at the 5-position. This electron-deficient scaffold integrates readily into bioactive molecule frameworks, offering enhanced metabolic stability and improved membrane permeability in pharmaceutical development.
5-Fluoro-2-methylindoline serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated indoline scaffolds prevalent in bioactive molecules. Its ortho-substituted structure provides enhanced metabolic stability and modulates electronic properties for target engagement. The molecule exhibits bench stability, facilitates straightforward functionalization at the indoline nitrogen, and demonstrates compatibility with standard coupling reactions and reductive amination protocols, making it well-suited for iterative synthesis campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: