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CS-W001157 4
Total: USD 88.00

2-(Chloromethyl)-5-methoxypyridine hydrochloride

  • CAS No. 82401-91-0

  • Cat. No. CS-0052239
  • Purity≥97%
  • MDL No.MFCD11109567
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

2-(Chloromethyl)-5-methoxypyridine hydrochloride|CS-0052239

Structure of 82401-91-0

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Description

2-(Chloromethyl)-5-methoxypyridine hydrochloride features a reactive chloromethyl group flanked by a methoxy-substituted pyridine ring, enabling efficient alkylation under mild conditions. The hydrochloride salt enhances solubility and stability in polar solvents, simplifying handling in synthetic workflows. This compound serves as a key intermediate for bioactive heterocycles and functionalized polymers.

Application

2-(Chloromethyl)-5-methoxypyridine hydrochloride serves as a versatile electrophilic building block for pyridine-based heterocycles, enabling efficient C–C and C–heteroatom bond formation. The chloromethyl group facilitates nucleophilic substitution under mild conditions, while the methoxy substituent provides moderate electronic stabilization and enhanced solubility. Bench-stable and readily purified by recrystallization, it functions reliably in standard coupling protocols and scaffold elaboration for medicinal chemistry applications.

General Information

  • CAS No. 82401-91-0
  • Cat. No. CS-0052239
  • Purity ≥97%
  • MDL No. MFCD11109567
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉Cl₂NO
  • Molecular Weight 194.06
  • Synonym(s) Pyridine, 2-(chloroMethyl)-5-Methoxy-, hydrochloride
  • SMILES Cl.COC1=CC=C(CCl)N=C1

Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.2508
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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