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Structure of 819869-77-7
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DOTA-tris(tBu)ester NHS ester features a highly reactive NHS ester group enabling efficient conjugation to primary amines under physiological conditions. The three tert-butyl esters provide enhanced solubility and stability, while the macrocyclic DOTA framework offers strong chelation for paramagnetic or radiometal ions. This derivative simplifies bioconjugation workflows in radiolabeling and molecular imaging applications.
DOTA-tris(tBu)ester NHS ester serves as a stable, bench-ready reagent for site-specific conjugation of DOTA chelating units to primary amines on biomolecules. Its tert-butyl ester groups enhance solubility and stability during storage, while the NHS ester functionality enables efficient coupling under mild aqueous conditions. This derivative facilitates the preparation of radiolabeled imaging agents and targeted therapeutics with high chelator incorporation efficiency and minimal side reactions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: