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CS-W001157 4
Total: USD 88.00

DOTA-tris(tBu)ester NHS ester

  • CAS No. 819869-77-7

  • Cat. No. CS-0133217
  • Purity≥98%
  • MDL No.MFCD26131244
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

DOTA-tris(tBu)ester NHS ester|CS-0133217

Structure of 819869-77-7

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Description

DOTA-tris(tBu)ester NHS ester features a highly reactive NHS ester group enabling efficient conjugation to primary amines under physiological conditions. The three tert-butyl esters provide enhanced solubility and stability, while the macrocyclic DOTA framework offers strong chelation for paramagnetic or radiometal ions. This derivative simplifies bioconjugation workflows in radiolabeling and molecular imaging applications.

Application

DOTA-tris(tBu)ester NHS ester serves as a stable, bench-ready reagent for site-specific conjugation of DOTA chelating units to primary amines on biomolecules. Its tert-butyl ester groups enhance solubility and stability during storage, while the NHS ester functionality enables efficient coupling under mild aqueous conditions. This derivative facilitates the preparation of radiolabeled imaging agents and targeted therapeutics with high chelator incorporation efficiency and minimal side reactions.

General Information

  • CAS No. 819869-77-7
  • Cat. No. CS-0133217
  • Purity ≥98%
  • MDL No. MFCD26131244
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₂H₅₅N₅O₁₀
  • Molecular Weight 669.81
  • Synonym(s) None
  • SMILES O=C(ON1C(CCC1=O)=O)CN2CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CCN(CC(OC(C)(C)C)=O)CC2

Computational Chemistry Data

  • TPSA   155.54
  • LogP   0.8403
  • H_Acceptors   14
  • H_Donors   0
  • Rotatable_Bonds   9

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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