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CS-W001157 4
Total: USD 88.00

2-Fluoro-5-nitrophenylboronic acid

  • CAS No. 819849-20-2

  • Cat. No. CS-W002992
  • Purity≥98%
  • MDL No.MFCD03092929

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-nitrophenylboronic acid|CS-W002992

Structure of 819849-20-2

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General Information

  • CAS No. 819849-20-2
  • Cat. No. CS-W002992
  • Purity ≥98%
  • MDL No. MFCD03092929
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BFNO₄
  • Molecular Weight 184.92
  • Synonym(s) B-(2-fluoro-5-nitrophenyl)-Boronic acid
  • SMILES OB(c1cc(ccc1F)[N+](=O)[O-])O

Description

2-Fluoro-5-nitrophenylboronic acid features a boronate moiety flanked by electron-withdrawing fluorine and nitro groups, enhancing its reactivity in Suzuki-Miyaura couplings. This bench-stable reagent integrates efficiently into complex molecular architectures under standard conditions.

Application

2-Fluoro-5-nitrophenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of biaryl scaffolds under mild conditions. The ortho-fluoro and meta-nitro substituents provide orthogonal reactivity and enhanced stability, facilitating selective functionalization and simplifying purification. Its bench-stable nature and compatibility with diverse reaction partners make it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   83.6
  • LogP   -0.5863
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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