Lot numbers can be found on the outside label of a product:
1-tert-Butyl 2-methyl 4-oxopiperidine-1,2-dicarboxylate
-
CAS No. 81357-18-8
- Cat. No. CS-W000565
- Purity≥96%
- MDL No.MFCD09842531
*For research and further manufacturing use only, not for direct human use.
Structure of 81357-18-8
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 81357-18-8
- Cat. No. CS-W000565
- Purity ≥96%
- MDL No. MFCD09842531
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₂H₁₉NO₅
- Molecular Weight 257.28
- Synonym(s) None
- SMILES O=C(N1C(C(OC)=O)CC(CC1)=O)OC(C)(C)C
Description
1-tert-Butyl 2-methyl 4-oxopiperidine-1,2-dicarboxylate features a sterically hindered piperidine core with orthogonal carbonyl and ester functionalities, enabling selective transformations in complex molecular architectures. The tert-butyl and methyl groups enhance stability and solubility under standard conditions, while the 4-oxo group provides a reactive handle for reductive amination and cyclization reactions.
Application
1-tert-Butyl 2-methyl 4-oxopiperidine-1,2-dicarboxylate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted piperidine scaffolds. The molecule combines a stable tert-butyl ester, a methyl-substituted nitrogen, and a ketone functionality, offering orthogonal reactivity for selective transformations. Its bench-stable nature and compatibility with standard coupling and reduction protocols facilitate streamlined synthesis of complex heterocycles and bioactive molecules.
Synthesis
-
Route1
-
In-stock
187753-13-5 - ~92%
-
In-stock
81357-18-8
References
-
AstraZeneca AB Patent: US6337343 B1, 2002 ; Location in patent: Page column 43-44 ; US 6337343 B1
-
-
Route2
-
In-stock
68014-21-1 - ~%
-
In-stock
81357-18-8
References
-
Tetrahedron Letters, , vol. 22, # 46 p. 4607 - 4610
-
-
Route3
-
81357-15-5 - ~%
-
In-stock
81357-18-8
References
-
Tetrahedron Letters, , vol. 22, # 46 p. 4607 - 4610
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 72.91
- LogP 1.128
- H_Acceptors 5
- H_Donors 0
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 81357-18-8 sigma81357-18-8 manufacturer81357-18-8 price81357-18-8 structure81357-18-8 SDSbuy 81357-18-881357-18-8 supplier81357-18-8 uses81357-18-8 molecular weightprice of 81357-18-881357-18-8 chemical name formula of 81357-18-8