5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

Name: 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine
Brand: ChemScene
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CAS No. 81265-93-2
Cat. No. CS-0021845
Purity≥96%
MDL No.MFCD00080294

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine|CS-0021845

Structure of 81265-93-2

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General Information

CAS No. 81265-93-2
Cat. No. CS-0021845
Purity ≥96%
MDL No. MFCD00080294
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄₄H₄₉N₅O₇Si
Molecular Weight 787.97
Synonym(s) None
SMILES O[C@H]1[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N2C(N=CN=C3NC(C4=CC=CC=C4)=O)=C3N=C2)O[C@@H]1COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7

Description

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine features a DMT group at the 5' position for solid-phase synthesis protection, a TBDMS moiety at the 2' position ensuring stability and selective deprotection, and a benzoyl group on the N7 nitrogen to prevent unwanted side reactions. This triply protected nucleoside enables efficient, high-fidelity oligonucleotide assembly under standard conditions.

Application

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine serves as a key protected nucleoside building block for the synthesis of oligonucleotides and modified RNA fragments. The DMT group enables efficient purification via chromatography, while the TBDMS protection at the 2'-position provides stability against degradation and facilitates orthogonal deprotection sequences. The N-Bz group ensures compatibility with standard phosphoramidite coupling protocols and supports high-yielding chain elongation in automated synthesis.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 139.08
LogP 7.7532
H_Acceptors 11
H_Donors 2
Rotatable_Bonds 13

Other Classifications

Life Science Nucleosides & Nucleotides 3'-Modified Nucleoside-phosphoramidite Monomer

Chemical Biology Nucleic Acid Chemistry Nucleoside Phosphoramidites

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Key Words

5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine sigma5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine manufacturer5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine price5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine structure5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine SDSbuy 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine supplier5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine uses5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine molecular weightprice of 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine chemical name formula of 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

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5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine

CAS No. 81265-93-2

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