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CS-W001157 4
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4-(Benzyloxy)-3-fluorophenol

  • CAS No. 81228-25-3

  • Cat. No. CS-W022003
  • Molecule weight218.22
  • Purity≥98%
  • MDL No.MFCD01814875

*For research and further manufacturing use only, not for direct human use.

4-(Benzyloxy)-3-fluorophenol|CS-W022003

Structure of 81228-25-3

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General Information

  • CAS No. 81228-25-3
  • Cat. No. CS-W022003
  • Purity ≥98%
  • MDL No. MFCD01814875
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₁FO₂
  • Molecular Weight 218.22
  • Synonym(s) None
  • SMILES OC1=CC(F)=C(OCC2=CC=CC=C2)C=C1

Description

4-(Benzyloxy)-3-fluorophenol features a fluorinated aromatic ring paired with a benzyloxy substituent, delivering enhanced electronic and steric properties. This combination enables selective functionalization in synthetic intermediates, particularly in pharmaceutical and agrochemical development. The molecule exhibits robust stability under standard conditions and facilitates efficient coupling reactions.

Application

4-(Benzyloxy)-3-fluorophenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds through standard coupling and functional group interconversion reactions. The benzyloxy group provides orthogonal protection for phenolic hydroxyls, facilitating selective transformations under mild conditions. Its stability under a range of reaction environments and compatibility with common synthetic protocols make it a practical choice for multi-step syntheses targeting bioactive molecules.

Synthesis

  • Route1
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    • In-stock
      4-(Benzyloxy)-3-fluorophenol|CS-W022003
      81228-25-3

    References

    • Journal of Medicinal Chemistry, , vol. 26, # 11 p. 1570 - 1576

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   3.1103
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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