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CS-W001157 4
Total: USD 88.00

4-Amino-1H-indazole-5-carboxylic acid

  • CAS No. 81115-63-1

  • Cat. No. CS-0162918
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Amino-1H-indazole-5-carboxylic acid|CS-0162918

Structure of 81115-63-1

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Description

4-Amino-1H-indazole-5-carboxylic acid features a fused bicyclic core with complementary electron-rich and acidic functionalities. The para-amino group enhances nucleophilicity, while the carboxylic acid enables direct conjugation or salt formation. This scaffold integrates readily into bioactive molecules requiring hydrogen bonding capacity and metabolic stability under standard conditions.

Application

4-Amino-1H-indazole-5-carboxylic acid serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient access to indazole-based scaffolds prevalent in medicinal chemistry. The molecule combines an electron-rich amine with a carboxylic acid for direct derivatization via amidation, esterification, or coupling reactions. Its stability under standard bench conditions and compatibility with diverse functional groups support reliable use in multi-step syntheses, including the construction of kinase inhibitors and other targeted therapeutics.

General Information

  • CAS No. 81115-63-1
  • Cat. No. CS-0162918
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N₃O₂
  • Molecular Weight 177.16
  • Synonym(s) None
  • SMILES O=C(C1=C(N)C2=C(NN=C2)C=C1)O

Computational Chemistry Data

  • TPSA   92
  • LogP   0.8433
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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