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CS-W001157 4
Total: USD 88.00

6-Bromo-2-chlorobenzothiazole

  • CAS No. 80945-86-4

  • Cat. No. CS-W014630
  • Molecule weight248.52
  • Purity≥98%
  • MDL No.MFCD04971822

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2-chlorobenzothiazole|CS-W014630

Structure of 80945-86-4

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General Information

  • CAS No. 80945-86-4
  • Cat. No. CS-W014630
  • Purity ≥98%
  • MDL No. MFCD04971822
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃BrClNS
  • Molecular Weight 248.52
  • Synonym(s) IFLAB-BB F1910-0018
  • SMILES BrC2=CC1=C(N=C(S1)Cl)C=C2

Description

A substitute for glutamine in mammalian cell culture media; stable to heat-sterilization.L-Alanyl-L-glutamine is used as a component in pharmaceuticals, cosmetics and food products. It is a stable Gln dipeptide, which protects mice against the jejunal crypt depletion in the setting of dietary protein and fat deficiency. It provides nutritional requirements, improves intestinal health and enhances the immune system. It is also involved in various clinical studies such as cancer treatment, radiation and chemotherapy. It finds application in biotechnology as a component for mammalian cell culture medium. It improves pancreatic beta-cell function, maintaining the mitochondrial metabolism and stimulus-secretion coupling essential for insulin release.

Synthesis

  • Route1

    References

    • CRITICAL THERAPEUTICS, INC. Patent: WO2007/146066 A2, 2007 ; Location in patent: Page/Page column 88-89 ;
  • Route2
    • (6-Bromo-benzothiazol-2-yl)-hydrazine|CS-0072506
      37390-63-9
    • ~93%
    • In-stock
      6-Bromo-2-chlorobenzothiazole|CS-W014630
      80945-86-4

    References

    • Byeon, Seong Rim; Jin, Yun Jung; Lim, Soo Jeong; Lee, Ji Hoon; Yoo, Kyung Ho; Shin, Kye Jung; Oh, Seung Jun; Kim, Dong Jin Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4022 - 4025
  • Route3

    References

    • Zhu, Lei; Zhang, Mingbao; Dai, Miao Journal of Heterocyclic Chemistry, 2005 , vol. 42, # 4 p. 727 - 730

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.7122
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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