Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,6-Naphthyridin-1(2H)-one

  • CAS No. 80935-77-9

  • Cat. No. CS-W019819
  • Purity≥97%
  • MDL No.MFCD06762736

*For research and further manufacturing use only, not for direct human use.

2,6-Naphthyridin-1(2H)-one|CS-W019819

Structure of 80935-77-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 80935-77-9
  • Cat. No. CS-W019819
  • Purity ≥97%
  • MDL No. MFCD06762736
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) 2,6-Naphthyridin-1-ol
  • SMILES O=C1NC=CC2=C1C=CN=C2

Description

2,6-Naphthyridin-1(2H)-one features a fused bicyclic core with dual nitrogen atoms at electron-rich positions, enabling strong hydrogen bonding and metal coordination. This scaffold integrates readily into bioactive molecules, offering enhanced solubility and metabolic stability in medicinal chemistry applications.

Application

2,6-Naphthyridin-1(2H)-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to biologically active scaffolds. Its inherent stability and compatibility with diverse functional groups facilitate downstream derivatization via nucleophilic substitution or metal-catalyzed coupling reactions. The molecule functions effectively as a hydrogen-bond acceptor and exhibits favorable solubility profiles, supporting its use in parallel synthesis campaigns and structure-activity relationship studies.

Synthesis

  • Route1
    • (E)-3-(2-(dimethylamino)vinyl)isonicotinonitrile|CS-0511855
      601514-61-8
    • ~66%
    • In-stock
      2,6-Naphthyridin-1(2H)-one|CS-W019819
      80935-77-9

    References

    • BRISTOL-MYERS SQUIBB COMPANY Patent: WO2009/158396 A1, 2009 ; Location in patent: Page/Page column 83-84 ;
  • Route2
    • null|null
      80935-76-8
    • ~65%
    • In-stock
      2,6-Naphthyridin-1(2H)-one|CS-W019819
      80935-77-9

    References

    • Haak, Henk J. W. van den; Plas, Henk C. van der; Veldhuizen, Beb van Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 1349 - 1352
  • Route3
    • 3-(2,2-Dimethoxyethyl)isonicotinamide|CS-1716810
      97308-58-2
    • ~42%
    • In-stock
      2,6-Naphthyridin-1(2H)-one|CS-W019819
      80935-77-9

    References

    • Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   45.75
  • LogP   0.9231
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2,6-Naphthyridin-1(2H)-one sigma2,6-Naphthyridin-1(2H)-one manufacturer2,6-Naphthyridin-1(2H)-one price2,6-Naphthyridin-1(2H)-one structure2,6-Naphthyridin-1(2H)-one SDSbuy 2,6-Naphthyridin-1(2H)-one2,6-Naphthyridin-1(2H)-one supplier2,6-Naphthyridin-1(2H)-one uses2,6-Naphthyridin-1(2H)-one molecular weightprice of 2,6-Naphthyridin-1(2H)-one2,6-Naphthyridin-1(2H)-one chemical name formula of 2,6-Naphthyridin-1(2H)-one
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label