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CS-W001157 4
Total: USD 88.00

3-(Aminomethyl)-1H-indazole

  • CAS No. 806640-37-9

  • Cat. No. CS-D1638
  • Molecule weight147.18
  • Purity≥97%
  • MDL No.MFCD06738683

*For research and further manufacturing use only, not for direct human use.

3-(Aminomethyl)-1H-indazole|CS-D1638

Structure of 806640-37-9

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General Information

  • CAS No. 806640-37-9
  • Cat. No. CS-D1638
  • Purity ≥97%
  • MDL No. MFCD06738683
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉N₃
  • Molecular Weight 147.18
  • Synonym(s) 1-(1H-Indazol-3-yl)methanamine; 3-(Aminomethyl)indazole; C-(1H-INDAZOL-3-YL)-METHYLAMINE
  • SMILES NCC1=NNC2=C1C=CC=C2

Description

3-(Aminomethyl)-1H-indazole is a nitrogen-rich heterocyclic scaffold featuring a pendant primary amine group. This functionalized indazole integrates readily into bioactive molecule design, offering enhanced solubility and hydrogen-bonding capacity. The compound demonstrates bench-stable handling under standard conditions and serves as a key building block in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active agents.

Application

3-(Aminomethyl)-1H-indazole serves as a versatile building block in medicinal chemistry, enabling efficient access to indazole-based pharmacophores. The primary amine functionality facilitates direct derivatization via amidation, alkylation, or reductive amination, while the indazole core provides metabolic stability and favorable binding interactions. Its bench-stable nature and compatibility with standard purification methods make it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • WO2008/54605 A2, ; Page/Page column 64 ; WO 2008/054605 A2

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.0216
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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