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Structure of 80517-21-1
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4-Fluoro-2-nitrobenzonitrile features a fluorine atom at the para position relative to the nitrile group, enhancing electrophilicity and enabling selective functionalization. The ortho-nitro group imparts strong electron-withdrawing character, facilitating nucleophilic aromatic substitution under mild conditions. This compound serves as a key building block in the synthesis of bioactive heterocycles and advanced pharmaceutical intermediates.
4-Fluoro-2-nitrobenzonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of substituted benzimidazoles and other heterocyclic scaffolds. Its orthogonal reactivity—combining electrophilic fluorine, nitro, and nitrile groups—facilitates sequential functionalization under mild conditions. The compound exhibits excellent bench stability and is readily purified by recrystallization, making it well-suited for scale-up and multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3439
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301+H311+H331-H315-H319-H335
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: