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CS-W001157 4
Total: USD 88.00

2,6-Bis(benzyloxy)pyridin-3-amine

  • CAS No. 803620-46-4

  • Cat. No. CS-0567098
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,6-Bis(benzyloxy)pyridin-3-amine|CS-0567098

Structure of 803620-46-4

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General Information

  • CAS No. 803620-46-4
  • Cat. No. CS-0567098
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₈N₂O₂
  • Molecular Weight 306.36
  • Synonym(s) None
  • SMILES NC1=CC=C(OCC2=CC=CC=C2)N=C1OCC3=CC=CC=C3

Description

2,6-Bis(benzyloxy)pyridin-3-amine features a pyridine core bearing two benzyloxy groups at the 2 and 6 positions and an amine at the 3 position. This configuration delivers enhanced solubility and stability while enabling selective coupling reactions in synthetic applications. The molecule’s electron-rich aromatic system supports efficient transition metal coordination, making it valuable for ligand development and complex heterocycle synthesis.

Application

2,6-Bis(benzyloxy)pyridin-3-amine serves as a versatile pyridine-based building block for medicinal chemistry and catalyst design. Its ortho-benzyloxy groups provide robust protection for phenolic-like functionalities while enabling selective deprotection under mild conditions. The pendant amine functions as a nucleophilic handle for conjugate additions or amide coupling, offering compatibility with standard synthetic workflows. Bench-stable and easily purified by chromatography, it facilitates the construction of complex heterocyclic scaffolds in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   57.37
  • LogP   3.8218
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

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