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CS-W001157 4
Total: USD 88.00

1-Cyclobutylpiperazine dihydrochloride

  • CAS No. 799557-65-6

  • Cat. No. CS-0052583
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclobutylpiperazine dihydrochloride|CS-0052583

Structure of 799557-65-6

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General Information

  • CAS No. 799557-65-6
  • Cat. No. CS-0052583
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈Cl₂N₂
  • Molecular Weight 213.15
  • Synonym(s) cyclobutylpiperazine dihydrochloride
  • SMILES Cl.Cl.C1CC(C1)N1CCNCC1

Description

1-Cyclobutylpiperazine dihydrochloride is a bench-stable, moisture-tolerant piperazine derivative featuring a cyclobutyl substituent that enhances lipophilicity and metabolic resilience. This structural motif enables efficient integration into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS modulators and kinase inhibitors. The dihydrochloride salt form ensures improved solubility and handling under standard conditions.

Application

1-Cyclobutylpiperazine dihydrochloride serves as a versatile nitrogen-containing building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its cyclobutyl-substituted piperazine core offers enhanced metabolic stability and modulated lipophilicity compared to simpler alkylated analogs. The dihydrochloride salt form ensures excellent solubility and bench stability, facilitating straightforward handling in standard synthetic workflows. It functions effectively as a key intermediate in the construction of heterocyclic compounds and peptide conjugates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   1.2877
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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