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CS-W001157 4
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5-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride

  • CAS No. 799274-07-0

  • Cat. No. CS-W022374
  • Molecule weight187.65
  • Purity≥98%
  • MDL No.MFCD05861553

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride|CS-W022374

Structure of 799274-07-0

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General Information

  • CAS No. 799274-07-0
  • Cat. No. CS-W022374
  • Purity ≥98%
  • MDL No. MFCD05861553
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁ClFN
  • Molecular Weight 187.65
  • Synonym(s) 5-FLUORO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
  • SMILES FC1=CC=CC2=C1CCNC2.[H]Cl

Description

5-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride is a bench-stable, moisture-tolerant heterocyclic amine featuring a fluorinated aromatic ring fused to a saturated nitrogen-containing core. This structure delivers enhanced metabolic stability and improved membrane permeability, enabling efficient incorporation into bioactive molecules for medicinal chemistry campaigns.

Application

5-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride serves as a valuable building block in medicinal chemistry, enabling efficient access to bioactive isoquinoline scaffolds. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the protonated amine facilitates salt formation for improved solubility and handling. The compound exhibits robust bench stability and functions effectively in standard coupling reactions, including reductive amination and electrophilic substitution, supporting diverse downstream derivatization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.8932
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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