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CS-W001157 4
Total: USD 88.00

3,5-Difluorobenzyl alcohol

  • CAS No. 79538-20-8

  • Cat. No. CS-W016402
  • Purity≥98%
  • MDL No.MFCD00010313

*For research and further manufacturing use only, not for direct human use.

3,5-Difluorobenzyl alcohol|CS-W016402

Structure of 79538-20-8

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General Information

  • CAS No. 79538-20-8
  • Cat. No. CS-W016402
  • Purity ≥98%
  • MDL No. MFCD00010313
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₂O
  • Molecular Weight 144.12
  • Synonym(s) (3,5-difluorophenyl)methanol
  • SMILES FC1=CC(F)=CC(CO)=C1

Description

3,5-Difluorobenzyl alcohol features a benzyl scaffold bearing two fluorine atoms at the 3 and 5 positions, enhancing electron deficiency and metabolic stability. This bench-stable, moisture-tolerant phenolic alcohol integrates readily into synthetic sequences requiring polar, aromatic building blocks with tuned electronic properties.

Application

3,5-Difluorobenzyl alcohol serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, electron-deficient aromatic handle for downstream functionalization. Its benzylic alcohol functionality supports straightforward derivatization via oxidation, protection, or coupling reactions. The ortho-fluorine substituents enhance metabolic stability and modulate electronic properties, while the compound exhibits good bench stability and compatibility with standard purification techniques.

Synthesis

  • Route1

    References

    • US6287646 B1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.4571
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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