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CS-W001157 4
Total: USD 88.00

3,5-Difluorobenzoic acid

  • CAS No. 455-40-3

  • Cat. No. CS-W016212
  • Purity≥98%
  • MDL No.MFCD00010323

*For research and further manufacturing use only, not for direct human use.

3,5-Difluorobenzoic acid|CS-W016212

Structure of 455-40-3

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General Information

  • CAS No. 455-40-3
  • Cat. No. CS-W016212
  • Purity ≥98%
  • MDL No. MFCD00010323
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₂O₂
  • Molecular Weight 158.10
  • Synonym(s) None
  • SMILES FC1=CC(F)=CC(C(O)=O)=C1

Description

3,5-Difluorobenzoic acid features a benzene ring bearing two fluorine substituents at the meta positions relative to the carboxylic acid group. This electron-deficient aromatic core enhances reactivity in coupling reactions and improves metabolic stability in bioactive molecule design. The compound exhibits excellent bench-stability and solubility in common organic solvents, enabling straightforward incorporation into synthetic sequences without specialized handling.

Application

3,5-Difluorobenzoic acid serves as a versatile building block in medicinal chemistry and materials science, enabling efficient incorporation of fluorinated aromatic motifs into target molecules. Its stability, compatibility with standard coupling reactions, and predictable electronic effects make it ideal for peptide synthesis, drug discovery, and the construction of heterocyclic scaffolds.

Synthesis

  • Route1
    • null|null
      124-38-9
    • null|null
      461-96-1
    • ~92%
    • In-stock
      3,5-Difluorobenzoic acid|CS-W016212
      455-40-3

    References

    • Schlosser, Manfred; Heiss, Christophe European Journal of Organic Chemistry, 2003 , # 23 p. 4618 - 4624
  • Route2
    • null|null
      124-38-9
    • null|null
      651027-07-5
    • ~94%
    • In-stock
      3,5-Difluorobenzoic acid|CS-W016212
      455-40-3

    References

    • Schlosser, Manfred; Heiss, Christophe European Journal of Organic Chemistry, 2003 , # 23 p. 4618 - 4624
  • Route3
    • null|null
      372-18-9
    • ~%
    • In-stock
      3,5-Difluorobenzoic acid|CS-W016212
      455-40-3

    References

    • Schlosser, Manfred; Heiss, Christophe European Journal of Organic Chemistry, 2003 , # 23 p. 4618 - 4624

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.663
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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