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Structure of 79456-33-0
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5-Chloro-3-(trifluoromethyl)pyridin-2-amine features a trifluoromethyl group at the 3-position and a chlorine substituent at the 5-position, creating a highly electron-deficient pyridine core. This combination enhances reactivity in cross-coupling processes and improves metabolic stability in bioactive molecule design. The amine functionality enables direct incorporation into pharmaceutical scaffolds via amidation or electrophilic substitution. Its bench-stable crystalline form facilitates handling under standard laboratory conditions.
5-Chloro-3-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling direct coupling reactions via its primary amine and electrophilic halogen. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloropyridine moiety facilitates palladium-catalyzed cross-coupling for C–C bond formation. Its bench-stable nature and compatibility with diverse functional groups make it ideal for constructing complex heterocyclic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: