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CS-W001157 4
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3,3-Dimethylpyrrolidine hydrochloride

  • CAS No. 792915-20-9

  • Cat. No. CS-0051614
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,3-Dimethylpyrrolidine hydrochloride|CS-0051614

Structure of 792915-20-9

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General Information

  • CAS No. 792915-20-9
  • Cat. No. CS-0051614
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClN
  • Molecular Weight 135.64
  • Synonym(s) tert-butyl 3-allyl-3-hydroxyazetidine-62-carboxylate
  • SMILES Cl.CC1(C)CCNC1

Description

3,3-Dimethylpyrrolidine hydrochloride offers a sterically hindered nitrogen center ideal for stabilizing reactive intermediates in synthesis. This bench-stable salt features enhanced solubility in polar media and facilitates efficient coupling reactions under mild conditions. The quaternary-like nitrogen environment enables robust nucleophilic behavior without significant basicity, making it valuable in pharmaceutical process development and asymmetric catalysis.

Application

3,3-Dimethylpyrrolidine hydrochloride serves as a stable, bench-ready nitrogen source in synthetic organic chemistry, facilitating the construction of saturated heterocyclic scaffolds. Its tertiary amine functionality enables efficient salt formation for improved solubility and handling, while the geminal dimethyl substitution enhances steric shielding and metabolic stability. This compound functions effectively in reductive amination protocols, acts as a building block for bioactive molecule synthesis, and exhibits excellent compatibility with common functional groups during multi-step transformations.

Synthesis

  • Route1
    • null|null
      73434-00-1
    • ~97%
    • In-stock
      3,3-Dimethylpyrrolidine hydrochloride|CS-0051614
      792915-20-9

    References

    • BOEHRINGER INGELHEIM INTERNATIONAL GMBH Patent: US2011/195954 A1, 2011 ; Location in patent: Page/Page column 89-90 ;
  • Route2

    References

    • SUMITOMO CHEMICAL COMPANY, LIMITED Patent: WO2004/99160 A1, 2004 ; Location in patent: Page 88 ;
  • Route3
    • null|null
      851429-33-9
    • ~%
    • In-stock
      3,3-Dimethylpyrrolidine hydrochloride|CS-0051614
      792915-20-9

    References

    • Jandeleit, Bernd; Li, Yunxiao; Gallop, Mark A.; Zerangue, Noa; Virsik, Peter A.; Fischer, Wolf-Nicolas Patent: US2009/82464 A1, 2009 ; Location in patent: Page/Page column 39 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.4277
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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