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(1R,2S,3R,5R)-3-Amino-5-(hydroxymethyl)cyclopentane-1,2-diol hydrochloride

  • CAS No. 79200-57-0

  • Cat. No. CS-0053627
  • Purity≥97%
  • MDL No.MFCD06799068

*For research and further manufacturing use only, not for direct human use.

(1R,2S,3R,5R)-3-Amino-5-(hydroxymethyl)cyclopentane-1,2-diol hydrochloride|CS-0053627

Structure of 79200-57-0

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General Information

  • CAS No. 79200-57-0
  • Cat. No. CS-0053627
  • Purity ≥97%
  • MDL No. MFCD06799068
  • Storage 4°C, stored under nitrogen, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO₃
  • Molecular Weight 183.63
  • Synonym(s) (1R,2S,3R,4R)-2,3-Dihydroxy-4-(Hydroxyme-Thyl)-1-Aminocyclopentane Hydrocloride
  • SMILES Cl.N[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O

Description

This cyclopentane diol scaffold features a stereochemically defined amino and hydroxymethyl group, delivering enhanced solubility and metabolic stability. The hydrochloride salt form ensures excellent crystallinity and shelf-life under standard conditions, enabling reliable use in synthetic intermediates for bioactive molecule development.

Application

This hydrochloride salt serves as a stable, bench-ready chiral building block for the synthesis of nucleoside analogs and bioactive heterocycles. Its four contiguous stereocenters provide defined stereochemistry essential for medicinal chemistry applications, while the amino and hydroxymethyl functionalities enable diverse functionalization. The compound exhibits good solubility and stability under standard handling conditions, facilitating purification and integration into multi-step synthetic sequences.

Synthesis

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      79200-54-7
    • ~%
    • In-stock
      (1R,2S,3R,5R)-3-Amino-5-(hydroxymethyl)cyclopentane-1,2-diol hydrochloride|CS-0053627
      79200-57-0

    References

    • WO2003/105770 A2, ; Page 46-47 ; WO 03/105770 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   86.71
  • LogP   -1.5305
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   1

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