tert-Butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate

Name: tert-Butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate
Brand: ChemScene
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CAS No. 790668-06-3
Cat. No. CS-0048630
Purity≥98%
MDL No.MFCD22415237

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate|CS-0048630

Structure of 790668-06-3

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General Information

CAS No. 790668-06-3
Cat. No. CS-0048630
Purity ≥98%
MDL No. MFCD22415237
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₁NO₃
Molecular Weight 215.29
Synonym(s) N-Boc-(2R,4S)-4-hydroxy-2-methylpiperidine
SMILES O=C(N1[C@H](C)C[C@@H](O)CC1)OC(C)(C)C

Description

tert-Butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate is a stereochemically defined piperidine derivative featuring a bench-stable tert-butyl carbamate protecting group and a chiral hydroxyl moiety. This configuration enables direct incorporation into complex heterocyclic scaffolds, particularly in medicinal chemistry campaigns targeting bioactive nitrogen-containing frameworks. The pendant hydroxyl group offers a handle for selective derivatization under mild conditions.

Application

tert-Butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate serves as a stereochemically defined chiral building block for the synthesis of bioactive piperidine derivatives. The protected hydroxyl and methylated nitrogen enable selective functionalization, while the tert-butyl ester facilitates straightforward deprotection under mild acidic conditions. Its bench-stable nature and compatibility with standard coupling reactions make it valuable in medicinal chemistry campaigns targeting CNS-active compounds and kinase inhibitors.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 49.77
LogP 1.7667
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

790668-06-3 sigma790668-06-3 manufacturer790668-06-3 price790668-06-3 structure790668-06-3 SDSbuy 790668-06-3790668-06-3 supplier790668-06-3 uses790668-06-3 molecular weightprice of 790668-06-3790668-06-3 chemical name formula of 790668-06-3

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tert-Butyl (2R,4S)-4-hydroxy-2-methylpiperidine-1-carboxylate

CAS No. 790668-06-3

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