Lot numbers can be found on the outside label of a product:
(S)-2-Amino-3-methyl-1,1-diphenylbutan-1-ol
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CAS No. 78603-95-9
- Cat. No. CS-W014609
- Purity≥95%
- MDL No.MFCD01318248
*For research and further manufacturing use only, not for direct human use.
Structure of 78603-95-9
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General Information
- CAS No. 78603-95-9
- Cat. No. CS-W014609
- Purity ≥95%
- MDL No. MFCD01318248
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₇H₂₁NO
- Molecular Weight 255.35
- Synonym(s) Benzenemethanol, alpha-[(1S)-1-amino-2-methylpropyl]-alpha-phenyl-
- SMILES OC(C1=CC=CC=C1)([C@@H](N)C(C)C)C2=CC=CC=C2
Description
(S)-2-Amino-3-methyl-1,1-diphenylbutan-1-ol features a chiral center flanked by two phenyl groups and a methyl substituent, delivering high stereochemical fidelity in asymmetric synthesis. The pendant primary amine and benzylic alcohol enable direct functionalization, while the sterically congested quaternary carbon enhances configurational stability under standard conditions. This scaffold serves as a robust building block for bioactive molecule assembly.
Application
(S)-2-Amino-3-methyl-1,1-diphenylbutan-1-ol serves as a chiral building block for medicinal chemistry applications, offering a rigid, sterically defined scaffold with high functional group tolerance. Its tertiary alcohol and primary amine functionalities enable straightforward derivatization, while the diphenylmethyl group imparts excellent bench stability and facilitates purification via crystallization or chromatography. This compound functions effectively in the synthesis of bioactive heterocycles and peptidomimetics under standard coupling conditions.
Synthesis
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Route1
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108-86-1 -
In-stock
6306-52-1 - ~88%
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In-stock
78603-95-9
References
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ARKIVOC (Gainesville, FL, United States), , vol. 2010, # 11 p. 370 - 379,10
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Route2
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100-59-4
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In-stock
6306-52-1
- ~61%
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In-stock
78603-95-9
References
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Organic Syntheses, , vol. 87, p. 26 - 35
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Route3
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57728-40-2
- ~%
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In-stock
78603-95-9
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In-stock
86695-06-9
References
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WO2010/148191 A2, ; Page/Page column 45-49; 64 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 46.25
- LogP 2.9058
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 4
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Key Words
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