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(R)-Methyl 2-amino-3-(tert-butoxy)propanoate hydrochloride

  • CAS No. 78537-14-1

  • Cat. No. CS-0094701
  • Molecule weight211.69
  • Purity≥97%
  • MDL No.MFCD00080901

*For research and further manufacturing use only, not for direct human use.

(R)-Methyl 2-amino-3-(tert-butoxy)propanoate hydrochloride|CS-0094701

Structure of 78537-14-1

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General Information

  • CAS No. 78537-14-1
  • Cat. No. CS-0094701
  • Purity ≥97%
  • MDL No. MFCD00080901
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₈ClNO₃
  • Molecular Weight 211.69
  • Synonym(s) O-Tert-Butyl-D-Serine Methyl Ester Hydrochloride
  • SMILES CC(C)(C)OC[C@@H](N)C(OC)=O.Cl

Description

(R)-Methyl 2-amino-3-(tert-butoxy)propanoate hydrochloride features a chiral α-amino ester scaffold with a moisture-tolerant tert-butoxy group, enabling reliable use in asymmetric synthesis. This bench-stable derivative integrates seamlessly into peptide backbone elaborations and catalytic transformations, delivering high diastereoselectivity in key bond-forming steps.

Application

(R)-Methyl 2-amino-3-(tert-butoxy)propanoate hydrochloride serves as a versatile chiral building block in peptide and heterocyclic synthesis. Its amine functionality enables straightforward derivatization, while the tert-butoxy group provides orthogonal protection for subsequent transformations. The hydrochloride salt enhances stability and solubility, facilitating handling and purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   61.55
  • LogP   0.7236
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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