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CS-W001157 4
Total: USD 88.00

2-(Benzyloxy)-4-bromo-1-methoxybenzene

  • CAS No. 78504-28-6

  • Cat. No. CS-0186436
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Benzyloxy)-4-bromo-1-methoxybenzene|CS-0186436

Structure of 78504-28-6

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General Information

  • CAS No. 78504-28-6
  • Cat. No. CS-0186436
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₃BrO₂
  • Molecular Weight 293.16
  • Synonym(s) 4-bromo-1-methoxy-2-phenylmethoxybenzene
  • SMILES COC1=C(C=C(C=C1)Br)OCC2=CC=CC=C2

Description

2-(Benzyloxy)-4-bromo-1-methoxybenzene features a benzyl ether linkage and bromine substituent positioned ortho to the methoxy group, enabling direct functionalization in cross-coupling reactions. This bench-stable aryl building block integrates seamlessly into complex molecular architectures under standard conditions.

Synthesis

  • Route1
    • In-stock
      5-Bromo-2-methoxyphenol|CS-W007658
      37942-01-1
    • null|null
      100-39-0
    • ~94%
    • In-stock
      2-(Benzyloxy)-4-bromo-1-methoxybenzene|CS-0186436
      78504-28-6

    References

    • Yu, Younong; Singh, Sudhir K.; Liu, Angela; Li, Tsai-Kun; Liu, Leroy F.; LaVoie, Edmond J. Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1475 - 1491
  • Route2

    References

    • Woodring, Jennifer L.; Bland, Nicholas D.; Ochiana, Stefan O.; Campbell, Robert K.; Pollastri, Michael P. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 21 p. 5971 - 5974
  • Route3
    • In-stock
      5-Bromo-2-methoxyphenol|CS-W007658
      37942-01-1
    • null|null
      100-44-7
    • ~47%
    • In-stock
      2-(Benzyloxy)-4-bromo-1-methoxybenzene|CS-0186436
      78504-28-6

    References

    • Chaffee, Alan L.; Cooke, Raymond G.; Dagley, Ian J.; Perlmutter, Patrick; Thomas, Raymond L. Australian Journal of Chemistry, 1981 , vol. 34, # 3 p. 587 - 598

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   4.0367
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   4

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